Ayatollah Khamenei says that the slogan "Death to America" refers to US policies and arrogance, not the the American nation.

This makes a big difference. If Iran declares a wish for genocide against Americans, we would have to consider Iran an enemy. But when it condemns only how the US government treats and has treated Iran (and possibly some other countries), Americans can easily recognize valid points in that criticism. This provides a basis for patriotic Americans to push for the changes in the US needed for reconciliation with Iran.

The remaining cause of friction between the US and Iran has to do with the Iranian regime's oppression of Iranians. Progressive Americans really care about these injustices. US plutocrats probably don't. If the US were to support Iran totally, that would be wrong, just as it is wrong for the US to support Saudi Arabia and Egypt today.

When Khamanei dies, there may be an opportunity for diplomats to lead both countries to correct their wrongs.